ABOUT (S)-PF-03716556

The structure of the unliganded double mutant HIV-one RT showed that Lys103Asn mutation facilitates coordination of a sodium ion with Lys101 O, Asn103 N and O(delta1), Tyr188 O(eta), and two water molecules. The development of the binding pocket involves the removing of the sodium ion. Although the RT by itself and also the RT/HBY 097 sophisticated